http://first.lifesciencedb.jp/archives/7831 WebMar 3, 2024 · Run domain Beclin-1 interacting and cysteine-rich containing protein。本研究グループの吉森教授らがオートファジーの抑制因子として発見したタンパク質である。PI3Kという酵素複合体に結合し、オートファゴソームとリソソームの融合を負に制御している。 ※4 抗酸化酵素
Beclin 1, Bcl-2 and Autophagy SpringerLink
WebAutophagy, an endogenous protective mechanism against hypoxic/ischemic injury, is correlated with the activation of the HIF-1α/Beclin1 signaling pathway. Based on … WebOct 12, 2024 · Autophagy is a tightly regulated catabolic process wherein cells under stress sequester cytosolic constituents like damaged proteins and organelles in double-membrane vesicles called autophagosomes. The autophagosomes degrade their cargo by lysosomal proteolysis generating raw materials for the biosynthesis of vital macromolecules. the box bulk shopping
【日記】オートファジーガード｜セナちゃん｜note
Beclin-1 is a protein that in humans is encoded by the BECN1 gene. Beclin-1 is a mammalian ortholog of the yeast autophagy-related gene 6 (Atg6) and BEC-1 in the C. elegans nematode. This protein interacts with either BCL-2 or PI3k class III, playing a critical role in the regulation of both autophagy and cell … See more Beclin-1 plays an important role in tumorigenesis, and neurodegeneration, being implicated in the autophagic programmed cell death. Ovarian cancer with upregulated autophagy has a less aggressive … See more BECN1 has been shown to interact with: • Bcl-2 • BCL2L2 • GOPC • MAP1LC3A See more • Funderburk SF, Wang QJ, Yue Z (June 2010). "The Beclin 1-VPS34 complex--at the crossroads of autophagy and beyond". Trends in Cell … See more Trehalose Trehalose reduces p62/Beclin-1 ratio and increases autophagy in the frontal cortex of ICR mice, possibly by increasing Beclin-1. See more • Human BECN1 genome location and BECN1 gene details page in the UCSC Genome Browser. • Overview of all the structural information available in the PDB for See more Webオートファジーの主要な因子の一つである Beclin1 が腫瘍抑制的な働きを有するとした報告（Liang et al., 1999）以後研究が進み、 p53 、Beclin2、 PTEN といった腫瘍抑制タ … the box burgers kirkland