2024 Cytoplasmic sox10

Cytoplasmic sox10

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August undefined, 2024

WebIn accord with its function as transcription factor, Sox10 contains two nuclear localization signals and is most frequently detected in the nucleus. In this study, we report that … WebIn ARM, cytoplasmic SOX10 was co-expressed with neuronal antigens in ~57% of submucosal and myenteric neurons, vs. ~3% in control. Furthermore, intrinsic gut neurons in ARM specimens co-expressed PLP1 (18%) and CDH19 (18%); however, neuronal co-expression of PLP1 and CDH19 was rarely (<2%) observed in controls.

SOX10 is a novel marker of acinus and intercalated …

WebSOX10 and S100 both stained 100% of DM and SCM, whereas Pan Melanoma stained 50% (Figure 3, Table 1). Normal lymph node was negative for SOX10 and Pan Melanoma but was strongly positive for S100 (Figure 4). The melanoma triple cocktail (Fast Red only) and the sequential double stain of SOX10 (DAB) and Pan Melanoma WebSOX10. −: − ± ... The cytoplasm is usually amphophilic and granular due to their secretory content. MTCs routinely express neuroendocrine markers as well as signs of thyroid differentiation (TTF1), whereas monoclonal PAX8 expression is lacking, as is thyroglobulin (the latter a consequence of the non-follicular cell origin). ... lewisburg eye care clinic

SOX10 is a novel marker of acinus and intercalated …

WebIn addition, a fourth pattern with cytoplasmic AE1/AE3 and nuclear SOX10 was observed in a subset of carcinomas, most notably triple-negative breast cancers. Conclusions: … WebMar 15, 2024 · SOX10 shows an increased specificity for soft tissue tumors of neural crest origin compared with S100 ( Appl Immunohistochem Mol Morphol 2012;20:445 ) MITF1 and SOX10 can be used to differentiate melanoma in situ from actinic keratosis with … WebMar 7, 2016 · Sox10 is a transcription factor of the sex determining region Y (SRY)-related high motility group (HMG)-box gene family. It plays an important role in the maintenance and migration of neural crest stem cells [ 1 – 4 ], and in their differentiation into neural crest-derived melanocytes and glia [ 5, 6 ]. mcclure watters

SOX10/keratin dual‐color immunohistochemistry: An

Sox10 is expressed in primary melanocytic neoplasms of various ...

WebAug 11, 2015 · SOX10 was negative in 10 cases of ITACs and 2 cases of non-ITACs, and positive in all other adenocarcinomas. The sensitivity of CK7-, CK20+, SOX10- and CDX2+ in primary ITACs of the sinonasal tract were 70.0%, 90.0%, 100%, 100%, respectively, and the specificity were 100%, 96.8%, 93.5%, 100%, respectively. Conclusions: WebOct 1, 2012 · Sox10 is a marker of neural crest origin and is expressed in melanoma and peripheral nerve sheath tumors. •. This article explores Sox10 expression in various … mcclure water treatmentWebMar 21, 2024 · SOX10 (SRY-Box Transcription Factor 10) is a Protein Coding gene. Diseases associated with SOX10 include Peripheral Demyelinating Neuropathy, Central … lewisburg flower shop

"WebThis granular cell tumor shows strong nuclear and cytoplasmic expression in virtually all of the tumor cells. The tumor cells surround a small peripheral nerve , which also expresses … " - Cytoplasmic sox10

Cytoplasmic sox10

Reliability of immunostaining using pan‐melanoma …

WebApr 5, 2013 · Nuclear staining of >10% tumor cells was considered positive for SOX10 and p63; cytoplasmic staining for Smooth muscle actin, calponin, CK14, CK5/6 and Glial fibrillary acidic protein; both ... WebNordic Immunohistochemical Quality Control, SOX10 run 60 2024 Page 1 of 9 Assessment Run 60 2024 Transcription factor SOX-10 (SOX10) Purpose Evaluation of the technical performance, level of analytical sensitivity and specificity of IHC tests among ... a weak cytoplasmic staining reaction of ganglion/neuronic cells in the appendix was accepted ...

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WebJan 1, 2014 · (B) Sox10 immunohistochemistry results in diffuse crisp nuclear staining in all granular tumor cells in cutaneous GCTs, 400×. (C) Noncutaneous GCTs from breast (top) and tongue (bottom), as well as other deep tissue sites, also showed diffuse nuclear staining in all granular tumor cells. WebJun 20, 2014 · Cytoplasmic staining for the pan-melanoma cocktail and nuclear staining for SOX10 and MITF were scored by 2 pathologists (J.C. and Y.G.). Positive staining in >1% …

WebJun 19, 2024 · In contrast to S100, which is expressed in both the nucleus and cytoplasm, SOX10 is confined to the nucleus, enabling double staining to be performed on paraffin … WebMay 5, 2009 · Others have shown that Sox10 is a nucleocytoplasmic shuttling protein. We extend this observation and demonstrate that, in the cytoplasm, Sox10 is peripherally associated with the mitochondrial outer membrane. Both Sox10 and ARMCX3 are expressed in mouse brain and spinal cord as well as several cell lines. Overexpression …

Web方法. 回顾性分析2016年2月至2024年1月上海市肺科医院与复旦大学附属肿瘤医院确诊的5例肺gct的临床资料、病理形态学特征及免疫表型特点，并复习相关文献。 WebApr 1, 2024 · We have previously shown that SOX10 is expressed in one hundred percent of primary human melanoma samples and that its expression is crucial for melanoma initiation, but also maintenance of...

WebApr 5, 2013 · Appropriate positive and negative controls were used for each antibody. Nuclear staining of >10% tumor cells was considered positive for SOX10 and p63; cytoplasmic staining for Smooth muscle actin...

WebJan 10, 2024 · To isolate single Sox10 + /FSP1 − cells from Sox10 + /FSP1 + cells, we plated the mixed cell population at very low density (~100 cells per 100-mm dish), and … lewisburg football schedule 2022WebJan 31, 2024 · The majority of tumors demonstrated 1 of 3 distinct patterns: 1) malignant melanomas with nuclear SOX10 (sensitivity of 94% and specificity of 95%); 2) epithelioid/pleomorphic sarcomas negative for … lewisburg first national bankWebSox10 shuttles between the nucleus and the cytoplasm. Since Sox10 can be found in the nucleus as well as in the cytoplasm, we addressed the question whether Sox10 has nucleocytoplasmic shuttling activity. An interspecies heterokaryon analysis was performed as originally described by Pinol-Roma and Dreyfuss . lewisburghamptoninn gmail.comWebAug 20, 2015 · Results: SOX-10 showed exclusive nuclear positivity in 100% of the uveal melanoma cases (38/38). HMB-45 showed cytoplasmic positivity in 97.3 (37/38). … lewisburg football twitterWebNuclear and cytoplasmic Expression in Normal Tissues [] This protein acts as a nucleocytoplasmic shuttle protein and is important for neural crest and peripheral nervous system development. In the central nervous system, … lewisburg funeral homes tnWebAug 27, 2024 · Animal studies have indicated that SOX10 is one of the key transcription factors regulating the proliferation, migration and differentiation of multipotent neural … lewisburg federal prison picturesWebSep 15, 2015 · Whereas SOX10 has a nuclear localisation in the embryonic neural crest, hEPI-NCSC showed predominantly cytoplasmic SOX10 immunoreactivity. WNT and SHH signalling are part of the network that regulates SOX10 expression ( Werner et al., 2007 ; McNeill et al., 2012 ), which explains the increased nuclear SOX10 localisation in hEPI … lewisburg flea market wednesday