Glut9 isoform2
WebSep 21, 2024 · transporter 9 (GLUT9) and urate transporter 1 (URAT1) are the primary candidates for urate reabsorption in the tubular system in humans and mice (31). Human GLUT9 is ex-pressed and operates primarily in the proximal tubule, where GLUT9 isoforms 2 and 1 [solute carrier family 2 member 9 (SLC2A9b and SLC2A9a)] are proposed to be … WebDownload scientific diagram Cloning of GLUT9 isoforms from 7-d embryo cDNA. Sevenday embryonic DNA was used as template to amplify GLUT9. The expected size for the full …
Glut9 isoform2
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Web1 day ago · Among the complications of diabetes, cardiovascular events and cardiac insufficiency are considered two of the most important causes of death. Experimental and clinical evidence supports the effectiveness of SGLT2i for improving cardiac dysfunction. SGLT2i treatment benefits metabolism, microcirculation, mitochondrial function, fibrosis, … WebKNOWAtlanta features 16 Metro Atlanta counties like Fulton, Cobb, Decatur and Gwinnett to help you choose the best area to live. Simply click on the county or city name to find …
WebApr 23, 2024 · This work aimed to investigate the effect of fucoidan (FPS) on urate transporters induced by uric acid (UA). The results showed that UA stimulated the expression of glucose transporter 9 (GLUT9) and urate transporter 1 (URAT1) in HK-2 cells, and FPS could reverse the effect. Moreover, UA could activate NF-κB, JNK and PI3K/Akt … WebSep 8, 2009 · We show that Glut9 is expressed in the basolateral membrane of hepatocytes and in both apical and basolateral membranes of the distal nephron. Mice with systemic knockout of Glut9 display moderate hyperuricemia, massive hyperuricosuria, and an early-onset nephropathy, characterized by obstructive lithiasis, tubulointerstitial inflammation, …
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massey longwood flWebBased on these results, one can conclude that the increased concen-tration of glucose in the lumen by SGLT2 inhibition stimulates uric acid excretion mediated by GLUT9 isoform 2 or any other transporter(s) in the proxi-mal tubule and inhibits uric acid reabsorption mediated by GLUT9 isoform2 in the collecting duct (Figure 8). hydrogen powered chpWeb進展過程で，血糖値は血清尿酸値に異なる影響を 及ぼすことが示された． 緒 言 比較的近年，メタボリックシンドロームの ... hydrogen powered cars safetyWebClinVar archives and aggregates information about relationships among variation and human health. hydrogen powered ferry san franciscoWebGlucose transporter 9 (GLUT9), which transports urate in an electrogenic and voltage-dependent manner, plays an important role in the maintenance of normal blood uric acid/urate levels. In the present study, we established a cell model based on the single-electrode patch-clamp technique for characte … massey manawatu library opening hoursWebAug 25, 2024 · Glut9-flox mice were constructed and hybrid with Alb-Cre mice to breed Glut9 liver-specific knockout (Glut9 Hep−ko) mice, and the Glut9-flox (Glut9 Fl/Fl) mice were used as control. The hepatic Glut9 knockdown effect was confirmed by detection of mRNA level of Glut9 in mouse liver samples (Supplementary Figure S2). massey machineWebMar 28, 2024 · Stuart CA, Yin D, Howell ME, Dykes RJ, Laffan JJ, Ferrando AA. Hexose transporter mRNAs for GLUT4, GLUT5, and GLUT12 predominate in human muscle. Am J Physiol Endocrinol Metab. 2006 Nov;291(5):E1067-73. doi: 10.1152/ajpendo.00250.2006. Epub 2006 Jun 27. hydrogen powered engine manufacturer