WebJan 1, 2013 · Hippuristanol is a small-molecule inhibitor that significantly blocks eIF4A-eIF4F activity (Bordeleau et al. 2006). Using these two compounds, in the present study, we show here, for the first time, that specific inhibition of eIF4F-mediated activities blocks the expression of protein synthesis-dependent long-term potentiation (LTP) in the ... WebThere is thus much interest in exploring eIF4F as a small molecule target for the development of new anticancer drugs. The DEAD-box RNA helicase, eIF4A, is an …
Hippuristanol - Wikipedia
WebMay 24, 2024 · Here, we show the application of carbene footprinting to the interaction between eIF4A helicase and a natural product inhibitor, hippuristanol, found in the coral Isis hippuris. Upon addition of hippuristanol we identified reduced carbene labelling (masking) in regions of eIF4A previously implicated in ligand binding. WebHippuristanol CAS NO.80442-78-0. Min.Order: 1 Metric Ton. FOB Price: USD $ 1.0-3.0/Metric Ton. hebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and … birch lake chiropractic clinic
Expeditious Synthesis of Hippuristanol and Congeners with …
WebIn addition, hippuristanol and pateamine A, two known inhibitors of eIF4A, failed to block HCV IRES-directed translation. To test the release of nuclear proteins to the cytoplasm and to analyze the formation of stress granules, the location of the nuclear protein TIA1 was tested by immunocytochemistry. Both arsenite and pateamine A could ... WebMar 15, 2011 · To investigate the mechanisms by which hippuristanol reduced the cell viability of HTLV-1-infected T-cell lines, we analyzed the frequency of apoptotic cells by immunostaining with Apo2.7, which specifically detects the 38 kDa mitochondrial membrane antigen 7A6 expressed on the mitochondrial outer membrane during apoptosis … WebTable of contents : Front Matter....Pages 0-0 Introduction to Marine Biotechnology....Pages 1-10 Front Matter....Pages 11-11 Marine Fungal Diversity and Bioprospecting....Pages 13-25 Diversity of Marine Phototorophs....Pages 27-34 Marine Viruses....Pages 35-49 Marine Microalgae....Pages 51-63 Seaweed Flora of the European North Atlantic and … dallasf/w news