How does thiazide cause hyponatremia
WebBackground: Thiazide diuretics are commonly used as first-line antihypertensive agents. Hyponatremia is a reported, though uncommon, complication of thiazide use. Although the exact mechanism of thiazide-induced hyponatremia (TIH) is unclear, it can be a significant cause of morbidity and mortality.
How does thiazide cause hyponatremia
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WebThe cause of hyponatraemia is often multifactorial. Common causes include: Medications (most commonly thiazide diuretics). Syndrome of inappropriate antidiuresis. Underlying medical conditions (such as heart failure, kidney disease, and liver disease). Most people with hyponatraemia are asymptomatic, particularly if it is mild and has developed ... WebCauses include: Medications, especially thiazide diuretics. Endocrine disorders (primary adrenal insufficiency). Cerebral salt-wasting (a rare cause of hyponatraemia resulting …
WebAug 13, 2024 · If you take a thiazide diuretic, your potassium level can drop too low (hypokalemia), which can cause life-threatening problems with your heartbeat. If you're on a potassium-sparing diuretic, you can have too much potassium in your blood. Other possible side effects of diuretics include: Dizziness Headaches Dehydration Muscle cramps WebDec 5, 2024 · increased thirst increased urination indigestion joint pain, stiffness, or swelling loss of appetite loss of heat from the body lower back or side pain muscle cramps or pain nausea or vomiting nosebleeds …
WebAmong the common causes of hypovolemic hyponatremia are GI fluid loss, a range of endocrinopathies [7], and thiazide-induced hyponatremia, which is best considered as a distinct entity, in particular because recent data suggest that it has a genetic predisposition. Also, the discontinuation of thiazide is a key ... WebThiazide diuretics are usually well-tolerated but can cause hyponatremia in people prone to low sodium, particularly the elderly. Role of vasopressin Vasopressin (also called antidiuretic hormone) is a substance naturally produced in the body that helps regulate the amount of water in the body by controlling how much water is excreted by the ...
WebApr 10, 2008 · In the Systolic Hypertension in the Elderly Program (SHEP), 4.1% of patients age 60 and over had at least one serum sodium ≤130 mEq/dL on chlorthalidone. 7 Female gender is generally recognized as a risk factor for thiazide-related hyponatremia, 8–11 especially, as in the present case, in women with low body weight who are more likely to ...
WebExample causes of drug induced hyponatraemia: Diuretics. thiazide diuretics indapamide; chlorothiazide; combination diuretics ... The content herein is provided for informational purposes and does not replace the need to apply professional clinical judgement when diagnosing or treating any medical condition. A licensed medical practitioner ... cyproheptadine rob hollandWebRisk factors for thiazide-associated hyponatremia include age, female sex, and possibly low body mass. A genetic susceptibility has recently been uncovered. Although frequently … binary search gfg javaWebFeb 5, 2015 · Hyponatremia (serum sodium <135 mEq/L) is present in about 20% of ADHF patients upon admission. The pathophysiology of hyponatremia in ADHF is more often dilutional rather than depletional (the latter is due to sodium wasting diuretics). Dilutional hyponatremia is due to impaired water excretion due to increased non-osmotic release of … binary search gfg practice solutionWebA 63-year-old white woman with a history of hypertension and chronic obstructive pulmonary disease presented to the emergency room with worsening shortness of breath, anorexia, coughing, increased thirst, and leg edema of two weeks' duration. cyproheptadine rxlist used forWebJun 12, 2012 · Listing a study does not mean it has been evaluated by the U.S. Federal Government. ... The drug of choice for diuresis has traditionally been furosemide. However, this drug cause hypernatremia (a rise in serum sodium) in a significant proportion of patients. Hypernatremia is traditionally treated by providing free water supplementation to … binary search graphWebFeb 12, 2024 · Inhibition of NCC by thiazides may produce relatively greater sodium loss in females as a result. Although the mean time to TAH after initiation of the drug was 19 … cyproheptadine sdsWebExplains how thiazides cause hyponatremia compared to loop diuretics due to the interstitial concentration gradient set up due to selective Na reabsorption a... cyproheptadine safe in pregnancy