2024 Sp1 function

Sp1 function

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August undefined, 2024

Web15. jan 2006 · Here we explored the post-translational modifications that may disrupt Sp1 function. Phospho-affinity purification of nuclear proteins revealed that resistant cells contained approximately 8-fold more phosphorylated Sp1 than parental cells; treatment of nuclear proteins from these cells with alkaline phosphatase restored GC-box binding. ... WebFig. 1, Sp1 also contains a small region of homology with the Drosophila protein buttonhead [35]. A yeast homolog of any of the Sp1 factors has yet to be identi-ﬁed based on sequence homology or conservation of its DNA binding ability. Moreover, no functional homolog has been found either. Sp1 contains two main transactivation domains, A

Inhibition of Sp1 Functions by Its Sequestration into PML …

WebOnly Sp1 contains a multimerization domain (beige) which facilitates interaction between multiple Sp1 molecules and promotes super-activation of genes. The position of the … Web15. sep 2009 · Sp1 expression levels show a dramatic increase during transformation and this could play a critical role for tumour development or maintenance. Although Sp1 deregulation might be beneficial for tumour cells, its overexpression induces apoptosis of untransformed cells. st paul mother day brunch buffet

Sp1 Transcription Factor - an overview ScienceDirect …

Web8. jan 2015 · Sp1 both activates and suppresses the expression of a number of essential oncogenes and tumor suppressors, as well as genes involved in essential cellular functions, including proliferation, differentiation, the DNA damage response, apoptosis, senescence and angiogenesis. WebSp1 both activates and suppresses the expression of a number of essential oncogenes and tumor suppressors, as well as genes involved in essential cellular functions, including … Web11. jan 2024 · Sp1 is a member of the Sp/Krüppel-like factor family and is a crucial transcription factor regulating normal physiological cell functions. Sp1 is also critical for the maintenance of epigenetic state, as it affects the methylation status of CG sequences within gene promoter regions. st paul morgantown

Sp1/Sp3 transcription factors regulate hallmarks of …

Transcription Factor Sp1 - an overview ScienceDirect …

Web京东承诺京东平台卖家销售并发货的商品，由平台卖家提供发票和相应的售后服务。请您放心购买！注：因厂家会在没有任何提前通知的情况下更改产品包装、产地或者一些附件，本司不能确保客户收到的货物与商城图片、产地、附件说明完全一致。 Web12. feb 2024 · Specific protein 1 (SP1) might act as a critical transcription regulator in myocardial infarction (MI), but little evidence about its function in regulating cardiac apoptosis, a major cause of MI development, has been revealed. roth christian saxonWeb19. mar 2015 · Sp1 and Sp3 belong to the specificity proteins (Sp)/Krüppel-like transcription factor family. They are closely related, ubiquitously expressed, and recognize G-rich DNA motifs. They are thought to regulate generic processes such as cell-cycle and growth control, metabolic pathways, and apoptosis. roth christian

"Web28. dec 2015 · Transcription factor Sp1 inhibition, memory, and cytokines in a mouse model of Alzheimer's disease Transcription factor Sp1 inhibition, memory, and cytokines in a … " - Sp1 function

Sp1 function

Web24. apr 2014 · Sp1 transcription factor controls a pleiotropic group of genes and its aberrant activation has been reported in a number of malignancies, including multiple myeloma. In this study, we investigate and report its aberrant activation in Waldenström macroglobulinemia (WM). The protein encoded by this gene is a zinc finger transcription factor that binds to GC-rich motifs of many promoters. The encoded protein is involved in many cellular processes, including cell differentiation, cell growth, apoptosis, immune responses, response to DNA damage, and chromatin remodeling. Post-translational modifications such as phosphorylation, acetylation, O-GlcNAcylation, and proteolytic processing significantly affect the activity of this protein, which c…

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WebThe distribution and function of individual distal Sp1 elements is less defined and appear to be more promoter-specific. Finally, data from transfected Drosophila cells provide the first direct proof for the involvement of Sp1 in the negative regulation of the ANT2 promoter and as a possible participant in repression of the beta-subunit promoter. Web4. apr 2024 · Summary. The protein encoded by this gene is a zinc finger transcription factor that binds to GC-rich motifs of many promoters. The encoded protein is involved …

Web21. mar 2024 · SP1 (Sp1 Transcription Factor) is a Protein Coding gene. Diseases associated with SP1 include Erythroleukemia and Embryonal Carcinoma. Among its … Transcription factor Sp1 (specificity factor 1) was traditionally viewed as a basal transcription factor responsible for the regulation of housekeeping genes. However, recent data have indicated that Sp1 is an important player in the DNA damage response (DDR), controlling cellular life/death decisions in the … Zobraziť viac As mentioned earlier, many cancer cells overexpress Sp1, which correlates with poor patient survival. Moreover, downregulation of Sp1 leads to decreased … Zobraziť viac A better understanding of the molecular mechanisms involved in genomic integrity checkpoint may explain how physiological populations of healthy … Zobraziť viac

WebSP1: Service Pack 1 (Microsoft) SP1: Serine Protease 1 (enzyme) SP1: Specific Protein 1 (biochemistry) SP1: Stimulatory Protein 1 (biochemistry) SP1: Scalable Powerparallel … Web8. jan 2015 · Sp1 both activates and suppresses the expression of a number of essential oncogenes and tumor suppressors, as well as genes involved in essential cellular …

Web31. okt 2016 · SP1 interacts physically with the two components of the peroxisome protein docking complex PEX13–PEX14 and the (RING)-finger peroxin PEX2. Loss of SP1 function suppresses defects of the pex14-2 and pex13-1 mutants, and SP1 is involved in the degradation of PEX13 and possibly PEX14 and all three RING peroxins.

st paul montgomery alWebSp1 both activates and suppresses the expression of a number of essential oncogenes and tumor suppressors, as well as genes involved in essential cellular functions, including proliferation, differentiation, the DNA damage response, apoptosis, senescence and … st paul mo city hallWebSp1 чрезвычайно широко экспрессирован в организме и регулирует множество генов. Гомолог Sp1 у дрозофилы — фактор btn (buttonhead) — участвует в сегментации … rothchur.chWebSP1: Special Project One. Miscellaneous » Automotive. Rate it: SP1: Specialist 1st Class Petty Officer. Governmental » Navy. Rate it: SP1: Sport Prototype One. Miscellaneous » … st paul monthly weatherWeb30. apr 2005 · Sp1 mediates the transcriptional regulation of several genes by means of various external signals. Glucose regulates the promoter activity of several genes via the Sp1 and Sp1 binding sites [34, 35]. Glucocorticoids and insulin are associated with the expression of some genes through the Sp1 function . roth christopherWeb7. júl 2024 · Dissecting the molecular function of this SP1 variant revealed a hypermorphic effect, triggering superactivation of Sp1-mediated transcription in the patients’ blood. To our knowledge, this is the first report of a naturally occurring germ line variant in SP1 that alters transcriptional networks and disrupts hematopoiesis in humans. roth christineWeb11. apr 2014 · PML inhibits Sp1-mediated transcriptional activation of the epidermal growth factor receptor (EGFR) gene by interacting with and preventing Sp1 from binding to its promoter. Our current study is to further understand the mechanistic insight of how PML interacts with Sp1 and inhibits Sp1 functions in vivo. roth cinema