WebSep 23, 2024 · However, SOX2 is a transcription factor, which makes direct targeting difficult. Thus, MLN4924 appears to be a promising SOX2-targeting agent via SOX2 depletion at the transcription level by inactivation of the FBXW2–MSX2 axis to abrogate cancer stem cells and to overcome drug resistance, 2 major causes of cancer therapeutic … WebAug 15, 2024 · The Sox2 transcription factor binds RNA. Nat. Commun. 2024; 11: 1805. Crossref; PubMed; Scopus (45) Google Scholar]. These TFs with DNA- and RNA-binding function can therefore orchestrate diverse cellular metabolisms by fine-tuning the expression of target genes at both transcriptional and post-transcriptional levels. …
The master transcription factor SOX2, mutated in anophthalmia ...
WebMar 13, 2024 · We report the unprecedented finding that the conserved RNA-binding motif protein, RBM24, positively controls Sox2 mRNA stability and is necessary for optimal SOX2 mRNA and protein levels in development, perturbation of which causes ocular defects, including microphthalmia and anophthalmia. WebJul 1, 2005 · Nanog, Sox2, and Oct4 are transcription factors all essential to maintaining the pluripotent embryonic stem cell phenotype. Through a cooperative interaction, Sox2 and Oct4 have previously been described to drive pluripotent-specific expression of a number of genes. We now extend the list of Sox2-Oct4 target genes to include Nanog. Within the … hermione\u0027s dress at slughorn\u0027s party
Regulation of Stem Cell Pluripotency and Differentiation Involves a …
WebCofactor flavin adenine dinucleotide (FAD), a compound with flavin moiety and a derivative of riboflavin (vitamin B2), is shown to bind to Sox9 (a key transcription factor in early pancreatic development) and, subsequently, induce a large increase in markers of pancreatic development, including Ngn3 and PTF1a. Pyridoxal 5′-phosphate (PLP), the active form of … WebMar 2, 2024 · INTRODUCTION. Essential cellular processes such as replication, recombination, and DNA repair occur alongside transcription on DNA. During transcription, RNA polymerase II (RNAPII) pauses at discrete sites, which in some instances is required for proper regulation of gene expression (1, 2).Prolonged pausing and/or stalling of the … WebApr 10, 2024 · The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this … hermione\\u0027s dress at slughorn\\u0027s party