site stats

The sox2 transcription factor binds rna

WebSep 23, 2024 · However, SOX2 is a transcription factor, which makes direct targeting difficult. Thus, MLN4924 appears to be a promising SOX2-targeting agent via SOX2 depletion at the transcription level by inactivation of the FBXW2–MSX2 axis to abrogate cancer stem cells and to overcome drug resistance, 2 major causes of cancer therapeutic … WebAug 15, 2024 · The Sox2 transcription factor binds RNA. Nat. Commun. 2024; 11: 1805. Crossref; PubMed; Scopus (45) Google Scholar]. These TFs with DNA- and RNA-binding function can therefore orchestrate diverse cellular metabolisms by fine-tuning the expression of target genes at both transcriptional and post-transcriptional levels. …

The master transcription factor SOX2, mutated in anophthalmia ...

WebMar 13, 2024 · We report the unprecedented finding that the conserved RNA-binding motif protein, RBM24, positively controls Sox2 mRNA stability and is necessary for optimal SOX2 mRNA and protein levels in development, perturbation of which causes ocular defects, including microphthalmia and anophthalmia. WebJul 1, 2005 · Nanog, Sox2, and Oct4 are transcription factors all essential to maintaining the pluripotent embryonic stem cell phenotype. Through a cooperative interaction, Sox2 and Oct4 have previously been described to drive pluripotent-specific expression of a number of genes. We now extend the list of Sox2-Oct4 target genes to include Nanog. Within the … hermione\u0027s dress at slughorn\u0027s party https://mcmanus-llc.com

Regulation of Stem Cell Pluripotency and Differentiation Involves a …

WebCofactor flavin adenine dinucleotide (FAD), a compound with flavin moiety and a derivative of riboflavin (vitamin B2), is shown to bind to Sox9 (a key transcription factor in early pancreatic development) and, subsequently, induce a large increase in markers of pancreatic development, including Ngn3 and PTF1a. Pyridoxal 5′-phosphate (PLP), the active form of … WebMar 2, 2024 · INTRODUCTION. Essential cellular processes such as replication, recombination, and DNA repair occur alongside transcription on DNA. During transcription, RNA polymerase II (RNAPII) pauses at discrete sites, which in some instances is required for proper regulation of gene expression (1, 2).Prolonged pausing and/or stalling of the … WebApr 10, 2024 · The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this … hermione\\u0027s dress at slughorn\\u0027s party

Sci-Hub The Sox2 transcription factor binds RNA. Nature ...

Category:Structural analysis and dimerization profile of the SCAN domain of …

Tags:The sox2 transcription factor binds rna

The sox2 transcription factor binds rna

Cancers Free Full-Text Targeting the Sonic Hedgehog Pathway …

WebApr 14, 2024 · Europe PMC is an archive of life sciences journal literature. WebJul 15, 2024 · Abstract. The transcription factor SOX2 is a vital regulator of stem cell activity in various developing and adult tissues. Mounting evidence has demonstrated the …

The sox2 transcription factor binds rna

Did you know?

WebNov 26, 2024 · SRY-box transcription factor 2 (SOX2) overlapping transcript (SOX2-OT) is an evolutionarily conserved long noncoding RNA. Its intronic region contains the SOX2 gene, the major regulator of the pluripotency of embryonic stem cells. The human SOX2-OT gene comprises multiple exons and has multiple tran … WebApr 14, 2024 · SOX2 can bind directly to ES2 lncRNA with high affinity through its DNA-binding HMG domain [144]. Numerous studies have reported aberrant expression of SOX2 …

WebB lymphoma Mo-MLV insertion region 1 homolog (BMI1) and SRY-Box Transcription Factor 2 (SOX2) are two CSC-related transcription factors that have been implicated in promoting CSC self-renewal. The objective of our current investigation was to determine the role of the Shh pathway in regulating BMI1 and SOX2 expression in thyroid cancer and ... WebSeveral recent studies have revealed that the Sox2 transcription factor binds RNA through its high-mobility group box (HMGB) domain in vitro and in vivo. A high degree of …

WebNov 1, 2024 · The Sox2 transcription factor binds RNA Nat. Commun., 11 ( 2024), p. 1805 View in Scopus Google Scholar 4. M.C. Pomeranz, et al. The Arabidopsis tandem zinc finger protein AtTZF1 traffics between the nucleus and cytoplasmic foci and binds both DNA and RNA Plant Physiol., 152 ( 2010), pp. 151 - 165 Google Scholar 5. W.C. Kim, et al. WebThere are two major termination strategies found in bacteria: Rho-dependent and Rho-independent. In Rho-dependent termination, the RNA contains a binding site for a protein called Rho factor. Rho factor binds to this …

WebNov 23, 2015 · NANOG is a transcription factor that occupies single-copy loci, as well as TEs including the ERV1 repeat family and LTR7 sequences in pluripotent stem cells 14, 24. We observed that HPAT2,...

WebApr 14, 2024 · Since SOX2 was reported to directly bind to the upstream regulatory region of human papillomavirus E6 to ... To identify genes regulated by SOX2, RNA sequencing (RNA-Seq) was performed in SOX2-OE and Ctl U251 cells. ... Ma YX, Ying MY et al. Reprogramming Transcription Factors Oct4 and Sox2 Induce a BRD-Dependent Immunosuppressive … hermione\\u0027s deathWebConclusion. Although the transcription factor Sox2 is generally thought of as a regulator of stem cell maintenance and regulation of differentiation, its role in orchestrating the many … hermione\\u0027s dress bill fleur\\u0027s weddingWebSox2 is a member of the Sox family of transcription factors, which have been shown to play key roles in many stages of mammalian development. This protein family shares highly … hermione\\u0027s dress for the yule ballWebAug 8, 2014 · Background The transcription factor, Sox2, is central to the behaviour of neural stem cells. It is also one of the key embryonic stem cell factors that, when overexpressed can convert somatic cells into induced pluripotent cells. Although generally studied as a transcriptional activator, recent evidence suggests that it might also repress … max factory srlWebDownloadable! Certain transcription factors are proposed to form functional interactions with RNA to facilitate proper regulation of gene expression. Sox2, a transcription factor … max factory san micheleWebSOX2 is required for multiple steps in formation of the trachea, lung, and esophagus. During these processes, SOX2 is complementarily expressed with other transcription factors, for … hermione\u0027s deathWebFatima Cavaleri, Hans Schöler, in Handbook of Stem Cells, 2004. OCT4 DOES NOT PLAY SOLO. Regulation of the FGF4 and UTF genes has provided insight into an Oct4-induced … max factory swimsuit saber figure