Thymidylate synthase翻译
WebbThis process is catalyzed by thymidylate synthase (TS or TYMS), a homodimer composed of two 30 kDa subunits. TS is an intracellular enzyme that provides the sole de novo source of thymidylate, making it a required enzyme in DNA biosynthesis with activity highest in proliferating cells (1). Being the exclusive source of dTMP, investigators have ... WebbWe have introduced the T4 thymidylate synthetase gene, resident in a 2.7-kilobase EcoRI restriction frag- ment, into an amplification plasmid, pKC30. By regu- lating expression of this gene from the phage XpL pro- moter within pKC3O in a thyA host containing a tem- perature-sensitive X repressor, the T4 synthetase could
Thymidylate synthase翻译
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Webb29 okt. 2024 · Thymidylate synthase is the rate-limiting enzyme required for DNA synthesis and overexpression of this enzyme causes resistance to cancer cells. Long treatments with 5-FU cause resistance to Thymidylate synthase targeting drugs. We have also compiled different mechanisms of drug resistance including autophagy and apoptosis, drug … WebbPrognostic significance of thymidylate synthase in postoperative non-small cell lung cancer patients Hong-Yun Zhao,1,* Guo-Wei Ma,1,* Ben-Yan Zou,1,* Mei Li,1 Su-Xia Lin,1 …
WebbA 978-base-pair gene that encodes thymidylate synthase (TS; 5,10-methylenetetrahydrofolate:dUMP C-methyltransferase, EC 2.1.1.45) from Lactobacillus … Webb词典,最权威的学习词典,为您提供thymidylate synthetase的在线翻译,thymidylate synthetase是什么意思,thymidylate synthetase的真人发音,权威用法和精选例句等。
Webb通过同源基因比对,在罗伯茨绿僵菌中找到了单拷贝的嘧啶前体合成酶基因MAA_02402,命名为MrThi12.该基因MrThi12全长1 234bp,cDNA序列全长1 029bp,编码342个氨基酸.构建同源重组载体,利用农杆菌介导的方法进行基因敲除.突变菌株在维生素B1缺乏的培养基上,生长很慢,菌丝形态异常,多分叉,完全不能产生气生菌丝 ... WebbPrognostic significance of thymidylate synthase in postoperative non-small cell lung cancer patients Hong-Yun Zhao,1,* Guo-Wei Ma,1,* Ben-Yan Zou,1,* Mei Li,1 Su-Xia Lin,1 Li-Ping Zhao,2 Ying Guo,1 Yan Huang,1 Ying Tian,1 Dan Xie,1 Li Zhang1 1Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative …
Webb31 juli 2001 · Thymidylate synthase (TS) is an important enzyme catalysing the reductive methylation of dUMP to dTMP that is further metabolized to dTTP for DNA synthesis.
WebbUniProtKB reviewed (Swiss-Prot) Organism. Enterobacteria phage T4 (Bacteriophage T4) Amino acids. 286. Protein existence. Evidence at protein level. Annotation score. 3/5. i am the mangle fnaf songWebbThe structural gene (TMP1) for yeast thymidylate synthetase (thymidylate synthase; EC 2.1.1.45) was isolated from a chimeric plasmid bank by genetic complementation in Saccharomyces cerevisiae.Retransformation of the dTMP auxotroph GY712 and a temperature-sensitive mutant (cdc21) with purified plasmid (pTL1) yielded Tmp + … i am the mangle lyricsWebb1 mars 1994 · The bifunctional enzyme dihydrofolate reductase–thymidylate synthase catalyses both the reductive methylation of 2′–deoxyuridylate and the subsequent reduction of dihydrofolate to yield 2 ... i am the mangle songWebb2004年中国人力资源开发网(www.chinahrd.net)联合国内多家知名媒体启动的中国“工作倦怠指数”调查，共有近4000名在职人士填写了问卷，调查结果显示，有70％的被调查者至少出现轻微的工作倦怠；39.22％的被调查者出现中度的工作倦怠；13％的被调查者出现高度工作倦怠。随着人们工作节奏的加快 ... i am the male lead\u0027s ex-girlfriend vfWebb10 mars 2024 · 智慧城市网为您推荐的产品T3抗原，三碘甲狀腺素T3抗原是由上海安研商贸有限公司提供，当前页面为T3抗原，三碘甲狀腺素T3抗原的产品详细介绍页面，包含了T3抗原，三碘甲狀腺素T3抗原产品的图片、价格、报价、型号、产地及供应商联系方式等信息。T3抗原，三碘甲狀腺素T3抗原 【简单介绍】【规 ... i am the mangle song lyricsWebbThe present study aimed to prospectively investigate the influence of thymidylate synthase (TS) polymorphisms (5'-TSER, 3'-TSUTR) on the disease-free survival (DFS) and overall survival (OS) of patients with colorectal cancer (CRC) who were treated with adjuvant 5-fluorouracil (5-FU) therapy. Patien … i am the man harley poeWebbThymidylate synthase (TS) is a key enzyme in the synthesis of 2'-deoxythymidine-5'-monophosphate, an essential precursor for DNA biosynthesis. For this reason, this … i am the manic whale